Academy Award-nominated comedy actress Teri Garr, whose sunny personality lights up the screen in movies like Young Frankenstein And TootsieHe died on Tuesday at the age of 79.

Garr earned an Oscar nomination for her role opposite Dustin Hoffman in the 1982 gender-bending comedy. TootsieHe died in Los Angeles of complications from multiple sclerosis, publicist Heidi Schaeffer said.

The actress announced in 2002 that she was diagnosed with MS after experiencing symptoms for nearly two decades. He became an advocate for MS research and treatment. Garr had surgery for a brain aneurysm in 2007 and used a wheelchair for a while.

“I had to learn to walk again, talk again, and think again, which I’m not even sure is necessary in Hollywood,” he joked in a 2008 interview.

Teri Ann Garr was born on December 11, 1944, in the Cleveland suburb of Lakewood, Ohio, into a show-business family: her father, Eddie, was a vaudeville performer and actor who performed on Broadway, and her mother, Phyllis, was a dancer in New York City. Radio City Music Hall as one of the Rockettes.

After attending college in Los Angeles, Garr moved to New York to pursue a career in ballet and then acting, training at the famous Actor’s Studio in Manhattan.