Clemson continues its quest for the College Football Playoff, one of the most important games of the tournament loaded Week 10 card.

The Tigers will host Louisville on Saturday night, who will try to break the host’s perfect ACC record in Death Valley. This is one of many matchups in Saturday’s headlines, so let’s start with the picks for each Top 25 matchup based on the spread.

Season Record: 65-79-1

Odds courtesy of FanDuel Sportsbook

Pick: Boise State (-23.5)

While San Diego State has made a lot of progress offensively under first-year head coach Sean Lewis and quarterback Danny O’Neil, I’m not sure the Aztecs’ offense can keep the Boise State defense out of the backfield.

The Broncos are tops in the nation in sacks this season, and the Aztecs defense is below the national average in sacks allowed (118th in total tackles for loss). The team will very often face obvious passing situations where Boise State can draw defenders back into coverage and create turnover-worthy plays for O’Neil.

While the Broncos may try to steal some rest from Ashton Jeanty, the team has too much firepower to beat SDSU at home.

Pick: Miami (Florida) (-21)

Pick: Arkansas (+7.5)

Pick: Army (-22.5)

Pick: Illinois (+3)

Pick: Ohio State (-3.5)

Pick: Iowa State (-14.5)

Pick: Oregon (-15.5)

Pick: Houston (+13.5)

Willie Fritz has had success as an underdog in his career, going 10-6 as an underdog against the spread, and I can see the Cougars competing quite a bit in this matchup against Kansas State, who remains in contention to be the favorite this season.

Despite going 7-1 in straight sets this season, the Wildcats haven’t been the best back-to-back team; He is 3-4 as a favorite against the difference and 1-3 ahead on the road.

Against a stingy Houston defense that ranks in the top 40 in points per drive allowed and 33rd in success rate allowed, I believe Avery Johnson may have a hard time putting up a tremendous effort. The sophomore point guard continues to fall short as a passer, making just eight big-time throws per game worth eight turnovers. Focused on Professional Football.

Pick: Michigan State (+7.5)

Pick: Florida (+16.5)

While Florida is probably second to none in this regard, I’ll take points for DJ Lagway showing his ability to make explosive plays frequently in this Gators offense.

Moreover, the Bulldogs have not been interested in gaining the upper hand against their opponents this season, but have yet to make a difference as the favorites since Week 1. The Gators’ offense, meanwhile, can stretch the field vertically with big-play catcher Lagway, who has averaged 12 yards per return this season.

Georgia received deep passes from the likes of Alabama and Mississippi State this season and ranked 42nd in coverage and 48th in explosive pass defense, according to PFF.

Pick: Texas A&M (-2.5)

Pick: Clemson (-10.5)

The Tigers offense hasn’t slowed down since Week 1, and I don’t expect that to happen in Week 10 either.

Clemson is averaging 48 points per game over the last six games and Louisville’s defense is smokey, playing its seventh straight game, and cracks are starting to appear in the big-play department. The Cardinals rank outside the top 100 in both explosive passing and run rate this season, allowing the Tigers to move the ball with ease on offense.

While Louisville has been competitive this season, I believe this matchup is the end of a stretch of football and the team will not have the energy to keep up with the explosive Clemson offense, which is tops in EPA/Play and averages around four. points per driver.

Pick: Tennessee (-16.5)

Pick: Pittsburgh (+7.5)

Match odds are updated periodically and may change.

Follow Reed on Twitter @ReedWallach and get all your college football betting betstamp @rw33

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.