There are only two ranked matchups on the college football schedule for Week 10, but that doesn’t mean the week isn’t worth watching.

No team is safe in college football and, crucially, the top-seeded teams continue to win in the first set of College Football Playoff rankings on Nov. 5.

Here are the five best matches of the week, listed in reverse order.

5. No. 13 Indiana (8-0) at Michigan State (4-4) | Saturday | 15:30 ET | peacock

The Hoosiers look like a legitimate College Football Playoff contender, but the program’s toughest stretch is here. The next three games will be at Michigan State, at home against Michigan, and at No. 4 seed Ohio State. The Spartans have lost four of their last five games, but two of their losses were by single points and the other two were to No. 1 Ohio State and No. 1 Oregon. Indiana’s defense will be key to earning the No. 9 seed.

Guess: Indiana’s defense defeated Michigan State and the Hoosiers remained undefeated, 37-10.

4. No. 19 Ole Miss (6-2) at Arkansas (5-3) | Saturday | noon ET | ESPN

In Lane Kiffin’s squad 19% chance Making the CFP with no room for error the rest of the season. SEC defenses have proven difficult. Ole Miss averaged 55 points per game in four games against non-SEC opponents, but averaged just 18 points in four SEC games. Raising gardens is no problem. Ole Miss ranks second in the nation with 538.1 yards per game. Maybe the Rebels can find their own inclination against Arkansas. The Hogs are allowing 22 points per game, which ranks 11th in the SEC.

Guess: The CFP is hoping to come away with a 31-28 loss to Ole Miss.

3.No. 10 Texas A&M (7-1) at South Carolina (4-3) | Saturday | 19:30 ET | ABC

This is another matchup where a top-seeded team could be poised for an upset against a lower-ranked opponent. South Carolina has had three losses this season but has been close to two blowout defeats. The Gamecocks lost by three points to -No. to No. 16 LSU in September and to No. 7 Alabama on Oct. 12 with two o’clock. Will they finally be able to move forward under the lights of their home? He’ll be coming to South Carolina’s defensive line against A&M’s running game. The Aggies rank ninth nationally in rushing offense, while South Carolina ranks 16th nationally in rushing defense.

Guess: The Gamecocks lost 24-19.

2. No. 18 Pitt (7-0) No. 20 SMU (7-1) | Saturday | 20:00 ET | ACC Network

Don’t forget ACC. It might not be the ranked ACC matchup many were expecting, but it should be fun to watch. SMU is a 30% chance Pitt has a 20% chance of making the playoffs. It’s a match that both must win and the points must be plentiful. Pitt ranks 25th nationally with 443.6 yards per game, while SMU ranks 26th with 443.5. SMU’s defense is superior and that should be the difference in the game.

Guess: Points come after points, but SMU prevails 42-35.

1. No. No. 4 Ohio State (6-1) 3 Penn State (7-0) | Saturday | noon ET | Fox

Can James Franklin finally beat the Buckeyes? Penn State has lost seven straight against Ohio State, and it won’t get any easier on Saturday. Penn State’s starting quarterback Drew Allar is a pregame decision after he suffered an injury in the first half at Wisconsin last week. Both teams have elite defenses and it may not take many points to win. For Franklin, a win over Penn State would change the narrative and give the Nittany Lions a clear path to the Big Ten title.

Guess: With or without Alls on Penn State, Ohio State prevails 27-21.