Christian McCaffrey will make his long-awaited 2024 NFL regular season debut in Week 10.

San Francisco 49ers running back has been sidelined with Achilles and calf injuries, but it’s time for one of the most popular fantasy football draft picks to take the field.

McCaffrey’s first opponent was the Tampa Bay Buccaneers, who allowed 4.9 yards per carry this season.

CeeDee Lamb will also start for the Dallas Cowboys on Sunday, but his production could take a hit with Dak Prescott out.

Below is a look at all the major injury news impacting Week 10 fantasy football matchups.

• Christian McCaffrey, RB, SF: Expected to play Sunday (calf/Achilles), According to Nick Wagoner of ESPN.com.
• Dak Prescott, QB, DAL: Out (hamstring), According to Jon Machota of The Athletic.
• Trevor Lawrence, QB, JAX: Tendency to not play (shoulder), According to NFL Network’s Ian Rapoport.
• Tony Pollard, RB, TEN: Returned to training on Friday (foot), According to Turron Davenport of ESPN.com.
• Tyjae Spears, RB, TEN: Turning backwards (hamstring), According to Jim Wyatt of Titans.com.
• Brian Robinson, RB, WSH: Output (hamstring), According to ESPN’s Jeremy Fowler.
• CeeDee Lamb, WR, DAL: Full credit for Sunday (shoulder), According to Machota.
• AJ Brown, WR, PHI: Full participant in Friday practice (knee), according to the team injury report.
• DeVonta Smith, WR, PHI: Full participant in Friday practice (hamstring), according to the team injury report.
• Nico Collins, WR, HOU: Questionable (hamstring), According to ESPN’s Adam Schefter.
• Mike Evans, WR, TB: None (hamstring), According to Greg Auman of Fox Sports.
• Chris Olave, WR, NO: Out (concussion), According to Schefter.
• Amari Cooper, WR, BUF: Questionable (wrist), According to Alaina Getzenberg of ESPN.com.
• Keon Coleman, WR, BUF: Out (wrist), According to Getzenberg.
• Michael Pittman Jr., WR, IND: Out (back), According to Schefter.
• Drake London, WR, ATL: Doubtful (cool), According to NFL.com.
• Adam Thielen, WR, VEHICLE: None (hamstring), According to Mike Kaye of the Charlotte Observer.
• Dallas Goedert, TE, PHI: Full participant in Friday practice (hamstring), according to the team injury report.
• Tyreek Hill, WR, MIA: Did not practice on Friday (ankle), According to Barry Jackson of the Miami Herald.

Christian McCaffrey to Make Season Debut

49ers head coach Kyle Shanahan called McCaffrey “ready to go” on Friday afternoon, according to ESPN’s Adam Schefter.